Diversity-oriented synthesis (DOS) is a research approach in the field of chemistry that focuses on the creation of diverse chemical libraries with the aim of discovering new bioactive molecules and potential drug candidates. DOS aims to generate structurally diverse compounds through the use of innovative synthetic methodologies, enabling the exploration of a wide range of chemical space and increasing the likelihood of identifying biologically relevant molecules. This approach is particularly important in drug discovery as it can help to identify new and unexpected chemical structures with unique biological activities. DOS has become an important strategy in the field of medicinal chemistry and has been used successfully in the development of new drugs for various therapeutic areas.